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Yeast multidrug resistance: the PDR network

E Balzi1, A Goffeau

  • 1Unité de Biochimie Physiologique, Université Catholique de Louvain, Louvain-la-Neuve, Belgium.

Journal of Bioenergetics and Biomembranes
|February 1, 1995
PubMed
Summary

This review details yeast gene networks controlling multidrug resistance. Transcription regulators like PDR1 and PDR3 govern drug extrusion pumps and other cellular functions, impacting yeast survival.

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Functional dissection of Pdr1p, a regulator of multidrug resistance in Saccharomyces cerevisiae.

Molecular genetics and genomics : MGG·2002

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Multidrug resistance (MDR) is a significant challenge in yeast, impacting cellular survival and therapeutic outcomes.
  • Understanding the genetic regulatory networks governing MDR is crucial for developing effective strategies.
  • The yeast Saccharomyces cerevisiae serves as a model organism for studying fundamental biological processes, including drug resistance.

Purpose of the Study:

  • To describe the gene network involved in multiple drug resistance in Saccharomyces cerevisiae.
  • To elucidate the roles of key transcription regulators in controlling the expression of drug resistance genes.
  • To highlight the involvement of ATP-binding cassette (ABC) transporters in yeast multidrug resistance.

Main Methods:

  • Literature review of studies on yeast multidrug resistance.
  • Analysis of gene expression data and regulatory interactions.
  • Identification of transcription factors and their target genes.

Main Results:

  • A network of transcription regulators, including PDR1, PDR3, PDR7, and PDR9, controls the expression of PDR5, an ATP-binding-cassette (ABC) transporter drug extrusion pump.
  • PDR1 regulates numerous other target genes, including additional ABC transporters (SNQ2, STE6, PDR10, PDR11, YOR1) and other membrane-associated or soluble proteins.
  • PDR3, along with PDR1, participates in co- and auto-regulation circuits essential for yeast multidrug resistance.

Conclusions:

  • The PDR network in S. cerevisiae involves intricate regulatory circuits controlling multiple drug resistance.
  • Transcription factors PDR1 and PDR3 play central roles in orchestrating the expression of drug efflux pumps and other genes.
  • This regulatory network is fundamental to yeast's ability to survive exposure to various drugs.

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