Differentiation of infected from noninfected rapidly progressive neuropathic osteoarthropathy

Differentiation of infected from noninfected rapidly progressive neuropathic osteoarthropathy can be difficult in a combined bone/111In-leukocyte study. We present two cases: one infected and one not infected. By examining the distribution of the 111In leukocyte activity and the change in the lesion-to-background ratios from the 4-hr to the 24-hr image, it may be possible to determine if the rapidly progressive neuropathic osteoarthropathy is infected.