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Related Experiment Videos

Effect of pH on injection phlebitis

P Simamora1, S Pinsuwan, J M Alvarez

  • 1Department of Pharmaceutical Sciences, College of Pharmacy, University of Arizona, Tucson 85721, USA.

Journal of Pharmaceutical Sciences
|April 1, 1995
PubMed
Summary

Formulation pH does not cause injection phlebitis. Studies show that pH levels between 3.0 and 11.0 are safe for intravenous bolus injections, preventing phlebitis incidence.

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Area of Science:

  • Pharmacology
  • Toxicology
  • Biochemistry

Background:

  • Phlebitis, an inflammation of veins, has been linked to formulation pH.
  • Understanding factors influencing phlebitis is crucial for safe drug administration.

Purpose of the Study:

  • To investigate the direct effect of formulation pH on the incidence of injection-induced phlebitis.
  • To determine the safe pH range for intravenous (IV) bolus injections concerning phlebitis.

Main Methods:

  • Rabbits were used as a model to assess phlebitis.
  • Buffers with varying pH values were administered via IV bolus injection.
  • Phlebitis was quantified using thermal measurements and visual evaluations.

Main Results:

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  • Formulation pH within the range of 3.0 to 11.0 did not induce phlebitis.
  • No significant correlation was found between pH and phlebitis incidence in the tested range.

Conclusions:

  • The pH of a formulation, between 3.0 and 11.0, does not appear to be a contributing factor to phlebitis.
  • This finding supports the safety of a wide pH range for IV bolus formulations, reducing concerns about pH-induced phlebitis.