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[Expression of E-cadherin in thyroid neoplastic tissues and its correlation with malignant and metastatic potential]
A Naitoh1, S Kobayashi, H Iwase
12nd Department of Surgery, Nagoya City University Medical School.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|July 1, 1995
Abstract:
Cadherin is an Ca2+ dependent adhesion molecules, which contribute to cell-cell adhesion and maintenance of tissue structures. Its decrease or functional abnormality plays an important vole in cancer invasion and metastasis. We investigate the expression of E- cadherin in thyroid neoplasms (papillary cancer, follicular cancer, medullary cancer anaplastic cancer and follicular adenoma) and normal thyroid. The decrease of E-cadherin expression in thyroid cancer correlates with its malignancy and metastatic potentiality.