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Childhood thrombosis

R Nuss1, T Hays, M Manco-Johnson

  • 1Department of Pediatrics, University of Colorado School of Medicine, Denver 80262, USA.

Pediatrics
|August 1, 1995
PubMed
Summary
This summary is machine-generated.

Pediatric thrombosis is linked to a high incidence of lupus anticoagulants and deficiencies in protein C and protein S. Further multicenter studies are needed to confirm these findings in children with thrombotic events.

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Area of Science:

  • Pediatric Thrombosis Research
  • Hematology
  • Vascular Medicine

Background:

  • Pediatric thrombotic events are a significant clinical concern.
  • Understanding risk factors and underlying conditions in pediatric thrombosis is crucial.

Purpose of the Study:

  • To evaluate demographic, clinical, and laboratory factors in children experiencing thrombotic events.
  • To determine the prevalence of specific prothrombotic conditions, including lupus anticoagulants and deficiencies in protein C and protein S.

Main Methods:

  • Retrospective data collection from 1987-1993 on children over 1 month old with thrombotic events.
  • Analysis of clinical data, family history, thrombotic site, and radiologic evaluations.
  • Evaluation for lupus anticoagulants and deficiencies of antithrombin III, protein C, and protein S.

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Main Results:

  • Sixty-one children (mean age 10 years) experienced thrombotic events, with equal sex distribution.
  • Central nervous system and central blood vessel thromboses were most common, often associated with central vascular access devices.
  • A high prevalence (two thirds) of evaluated children had lupus anticoagulants or deficiencies in protein C or protein S, particularly those without underlying prothrombotic conditions.

Conclusions:

  • Preliminary findings suggest a high incidence of lupus anticoagulants and protein C/protein S deficiency in pediatric thrombosis.
  • Prospective, multicenter studies are recommended to validate these observations in pediatric populations.