Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Solvent interactions with pi ring systems in proteins

K Flanagan1, J Walshaw, S L Price

  • 1Department of Crystallography, Birkbeck College, University of London, UK.

Protein Engineering
|February 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Water-soluble contrast agent use in adhesional small bowel obstruction: a survey of surgical practices and clinical trial considerations.

Annals of the Royal College of Surgeons of England·2025
Same author

Urban stormwater quality: A review of methods for continuous field monitoring.

Water research·2023
Same author

PRESS survey: PREvention of surgical site infection-a global pan-specialty survey of practice protocol.

Frontiers in surgery·2023
Same author

Ion Heating and Flow Driven by an Instability Found in Plasma Couette Flow.

Physical review letters·2021
Same author

Laboratory Resolved Structure of Supercritical Perpendicular Shocks.

Physical review letters·2021
Same author

Shifting sows: longitudinal changes in the periparturient faecal microbiota of primiparous and multiparous sows.

Animal : an international journal of animal bioscience·2021
Same journal

Structure of a human Rhinovirus complexed with its receptor molecule.

Protein engineering·2024
Same journal

pH-responsive polymer-assisted refolding of urea- and organic solvent-denatured alpha-chymotrypsin.

Protein engineering·2004
Same journal

Evaluation of different linker regions for multimerization and coupling chemistry for immobilization of a proteinaceous affinity ligand.

Protein engineering·2004
Same journal

Recombinant porcine intestinal carboxylesterase: cloning from the pig liver esterase gene by site-directed mutagenesis, functional expression and characterization.

Protein engineering·2004
Same journal

Periplasmic expression of human growth hormone via plasmid vectors containing the lambdaPL promoter: use of HPLC for product quantification.

Protein engineering·2004
Same journal

Shift of fibril-forming ability of the designed alpha-helical coiled-coil peptides into the physiological pH region.

Protein engineering·2004
See all related articles

Water molecules interact with phenylalanine

Area of Science:

  • Biochemistry
  • Structural Biology
  • Computational Chemistry

Background:

  • The hydrophobic effect is crucial for protein folding.
  • Understanding water-amino acid interactions informs protein structure and function.

Purpose of the Study:

  • To investigate water molecule interactions with phenylalanine residues.
  • To determine the preferred binding sites of water on phenylalanine in proteins.

Main Methods:

  • Utilized a distributed multiple electrostatic model for theoretical calculations.
  • Analyzed 48 high-resolution protein structures to observe real-world interactions.

Main Results:

  • Theoretical models show minimum energy sites for water interaction above phenylalanine's aromatic pi electrons.

Related Experiment Videos

  • Protein structure analysis reveals dominant water interaction occurs at the ring's edge, not the pi face.
  • Buried ring faces and favorable interactions with neighboring polar atoms limit pi-face hydration.

    • Conclusions:

    • Water's interaction with phenylalanine pi electrons is sterically and energetically limited within protein structures.
    • Solvent interactions with phenylalanine edges are more prevalent in proteins than face-based pi-electron hydration.