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Gene-modified cells for the treatment of cancer
K A Whartenby1, G N Abraham, P A Calabresi
1Department of Medicine, University of Rochester Medical Center, NY 14642, USA.
Abstract:
Gene therapy involves the insertion of a gene into an organism to treat a disease. Since its early development in the 1970s, gene therapy has expanded rapidly both in terms of the methods available and the number of candidate diseases for treatment. This report reviews gene therapy for cancer, including methodology, pre-clinical studies and experimental clinical trials.
Insights
Gene therapy introduces genes to combat disease. This review covers cancer gene therapy methods, pre-clinical research, and ongoing clinical trials, highlighting its rapid advancement.
Area of Science:
- Oncology
- Molecular Biology
- Biotechnology
Background:
- Gene therapy, a technique for treating diseases by inserting genes, has evolved significantly since the 1970s.
- The field has seen rapid expansion in available methodologies and the range of target diseases.
Purpose of the Study:
- To provide a comprehensive review of gene therapy applications in cancer treatment.
- To summarize current methodologies, pre-clinical findings, and experimental clinical trials in cancer gene therapy.
Main Methods:
- Literature review of gene therapy techniques.
- Analysis of pre-clinical studies in cancer models.
- Overview of experimental clinical trials for cancer gene therapy.
Main Results:
- Gene therapy offers diverse methodologies for cancer treatment.
- Pre-clinical studies demonstrate potential efficacy.
- Experimental clinical trials are exploring various gene therapy strategies for cancer.
Conclusions:
- Gene therapy is a rapidly advancing field with significant potential in oncology.
- Continued research and clinical trials are crucial for realizing the full therapeutic benefits of gene therapy for cancer patients.