Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ventroposterolateral pallidotomy

L V Laitinen1

  • 1Sophiahemmet Hospital, Stockholm, Sweden.

Stereotactic and Functional Neurosurgery
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Parkinson's disease symptoms like bradykinesia stem from medial globus pallidus hyperactivity. Surgical pallidotomy and thalamotomy alleviate motor deficits and improve psychomotor functions, supporting this concept.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

My 50 years of interest in stereotactic and functional neurosurgery.

Stereotactic and functional neurosurgery·2002
Same author

Psychosurgery.

Stereotactic and functional neurosurgery·2002
Same author

Surgical treatment for Parkinson's disease over the last decade.

Advances in neurology·2001
Same author

Leksell's unpublished pallidotomies of 1958-1962.

Stereotactic and functional neurosurgery·2000
Same author

Dilated perivascular spaces in the putamen and pallidum in patients with Parkinson's disease scheduled for pallidotomy: a comparison between MRI findings and clinical symptoms and signs.

Movement disorders : official journal of the Movement Disorder Society·2000
Same author

Behavioral complications of early pallidotomy.

Brain and cognition·2000

Area of Science:

  • Neuroscience
  • Neurology
  • Movement Disorders

Background:

  • Dopamine deficiency in Parkinson's disease (PD) leads to medial globus pallidus (MGP) hyperactivity, causing motor symptoms like bradykinesia, rigidity, and tremor.
  • Previous studies suggest surgical lesions in the ventroposterolateral (VPL) pallidum can improve parkinsonian motor deficits and L-dopa-induced dyskinesias.

Purpose of the Study:

  • To investigate the effects of VPL pallidotomy and thalamotomy on psychomotor functions in patients with Parkinson's disease.
  • To further support the hypothesis that parkinsonian symptoms originate in the MGP.

Main Methods:

  • The study involved patients undergoing VPL pallidotomy and VPL/ventrolateral thalamotomy.
  • Assessment of motor functions including walking speed, manual dexterity, and verbal performance was conducted.

Related Experiment Videos

Main Results:

  • VPL pallidotomy significantly improved bradykinesia, tremor, rigidity, walking speed, and manual dexterity.
  • L-dopa-induced dyskinesias were reduced or eliminated post-VPL pallidotomy.
  • Right-sided VPL thalamotomy enhanced verbal performance speed and accuracy.
  • Ventrolateral thalamotomy was observed to increase bradykinesia.

Conclusions:

  • The findings reinforce the concept that MGP hyperactivity is central to the development of parkinsonian motor symptoms.
  • Intact neural pathways from the MGP through the thalamus to the motor cortex are crucial for normal motor control.
  • Pallidotomy and thalamotomy represent viable surgical interventions for managing specific aspects of Parkinson's disease.