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Related Experiment Videos

Le(a) and Le(b) tissue glycosphingolipids

R Hauser1

  • 1Department of Forensic Medicine, Gdansk Medical School, Poland.

Transfusion
|July 1, 1995
PubMed
Summary
This summary is machine-generated.

Plasma and red cell Lewis antigens (Le(a) and Le(b)) may be synthesized by epithelial and mesodermal tissues. Digestive tract epithelial cells are a potential source for plasma-borne Lewis antigens.

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Area of Science:

  • Biochemistry
  • Immunology
  • Human Physiology

Background:

  • The synthesis of Lewis a (Le(a)) and Lewis b (Le(b)) antigens is primarily associated with exocrine secretions.
  • The precise origin of plasma and red blood cell Le(a) and Le(b) antigens remains unclear.

Purpose of the Study:

  • To investigate the tissue-specific synthesis of Le(a) and Le(b) antigens.
  • To determine the origin of Lewis antigens found in plasma and on red blood cells.

Main Methods:

  • Extraction of Le(a) and Le(b) glycolipids from human tissues using chromatographic techniques.
  • Utilizing immunochemical methods for antigen identification and analysis.

Main Results:

  • Evidence suggests that both epithelial and mesodermal tissues can synthesize Le(a) and Le(b) antigens.

Related Experiment Videos

  • Lewis transferase activity was detected in various tissues, confirming gene interactions (Le and H) in Leb antigen formation.

    • Conclusions:

    • Plasma-borne Le(a) and Le(b) substances may originate from epithelial cells within the digestive tract.
    • This finding clarifies the source of circulating Lewis antigens.