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A prospective two-year study of progestin given alone in postmenopausal women: effect on lipid and metabolic
F A Trémollieres1, J M Pouilles, C A Ribot
1Unité Fonctionnelle Maladies Osseuses et Métaboliques, Centre Hospitalier Universitaire Purpan, Toulouse, France.
Objective:
A controlled study was conducted to assess the long-term effect of a progestin with very low androgenic potency given alone on serum lipoprotein profile, serum renin substrate, sex hormone-binding globulin levels, and serum antithrombin III activity in early postmenopausal women.
Study Design:
Thirty-five early postmenopausal women who had not received any form of hormonal treatment after menopause were randomly assigned to a 2-year regimen of 500 micrograms of a progestin derived from 19-norprogesterone (promegestone) or a placebo for 21 days of a 28-day treatment cycle. Serum lipid and lipoprotein levels and other biochemical parameters were measured in the two groups, and differences were sought by statistical analysis.
Results:
After 2 years of treatment the women in the two groups showed no statistically significant variation from baseline values in the concentrations of any of the biochemical parameters studied.
Conclusions:
The results show that a progestin with very low androgenic activity given alone has no influence on lipid profile and hepatic synthesis of several proteins in early postmenopausal women.