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Primary cerebral gliosarcoma: report of 17 cases
H C Parekh1, D G O'Donovan, R R Sharma
1Department of Neurosurgery, Royal Preston Hospital, UK.
British Journal of Neurosurgery
|April 1, 1995
Summary
Primary cerebral gliosarcoma is a rare, aggressive brain tumor. Despite treatment, median survival was only 9 months, highlighting the need for further research into this aggressive neoplasm.
Area of Science:
- Neuro-oncology
- Pathology
- Neurosurgery
Background:
- Primary cerebral gliosarcoma is an uncommon and highly aggressive intracranial neoplasm.
- This retrospective study analyzes 17 cases diagnosed between 1973 and 1992.
Purpose of the Study:
- To highlight the clinical, radiological, and pathological features of primary cerebral gliosarcoma.
- To compare and contrast gliosarcoma with glioblastoma.
Main Methods:
- Retrospective analysis of 17 primary cerebral gliosarcoma cases.
- Utilized histochemistry and immunohistochemistry for detailed pathological examination.
- Reviewed clinical, radiological, and treatment data.
Main Results:
- Patients ranged from 21 to 73 years (mean 52), with a slight male predominance.
- Symptoms indicated a rapidly expanding brain tumor.
- Median survival was poor at 9 months despite surgical excision, radiotherapy, and chemotherapy.
Conclusions:
- Primary cerebral gliosarcoma is an aggressive tumor with a poor prognosis.
- Combined histochemistry and immunohistochemistry are crucial for diagnosis and understanding.
- Further research is needed to improve outcomes for this rare brain malignancy.