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Intraperitoneal erythropoietin treatment of children with chronic renal failure

B T Steele1, A Vigneux

  • 1Department of Paediatrics, McMaster University Medical Centre, Hamilton, Ontario, Canada.

Pediatric Nephrology (Berlin, Germany)
|June 1, 1995
PubMed

Insights

Intraperitoneal erythropoietin effectively improved hemoglobin in children on peritoneal dialysis over six months. This method is cost-effective and avoids the pain associated with subcutaneous injections.

Area of Science:

  • Pediatric Nephrology
  • Renal Replacement Therapy
  • Hematology

Background:

  • Chronic kidney disease in children often leads to anemia.
  • Erythropoietin is a standard treatment for anemia in dialysis patients.
  • Subcutaneous administration of erythropoietin can cause local pain and discomfort.

Purpose of the Study:

  • To evaluate the efficacy and safety of intraperitoneal erythropoietin administration in children undergoing chronic peritoneal dialysis.
  • To assess the cost-effectiveness of the intraperitoneal route compared to subcutaneous administration.

Main Methods:

  • Three children on chronic peritoneal dialysis received intraperitoneal erythropoietin.
  • Doses ranged from 100 to 150 units/kg, administered undiluted into a dry peritoneal cavity twice weekly.
  • Erythropoietin remained in the cavity for 10-12 hours before resuming dialysis.

Main Results:

  • Satisfactory hemoglobin levels were achieved and maintained over a 6-month study period.
  • No complications related to intraperitoneal erythropoietin administration were observed.
  • The intraperitoneal route demonstrated cost-effectiveness.

Conclusions:

  • Intraperitoneal erythropoietin is a safe and effective alternative for managing anemia in pediatric patients on peritoneal dialysis.
  • This administration route offers a cost-effective solution and improves patient comfort by avoiding subcutaneous injection pain.

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