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Behavioural assessment of endothelin-1 induced middle cerebral artery occlusion in the rat
H M Marston1, E S Faber, J H Crawford
1Fujisawa Institute of Neuroscience, Department of Pharmacology, University of Edinburgh, UK.
Abstract:
The behavioural effects of unilateral middle cerebral artery occlusion (MCAO) induced by perivascular injection of endothelin, and a unilateral excitotoxic lesion of the striatum, were explored using the staircase test of skilled paw-reaching in the rat. A profound bilateral impairment in pellet recovery, with a concomitant increase in pellet displacement, was observed in the MCAO group. By contrast the striatal lesion group exhibited a primarily contralateral impairment. The findings provide both further insight into the control of unilateral motor function and a reliable behavioural endpoint for the assessment of experimental stroke.