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Torsemide: a pyridine-sulfonylurea loop diuretic
J S Blose1, K F Adams, J H Patterson
1University of North Carolina at Chapel Hill 27599, USA.
The Annals of Pharmacotherapy
|April 1, 1995
Summary
Torsemide is a loop diuretic with good bioavailability and once-daily dosing, offering therapeutic efficacy comparable to furosemide for conditions like heart failure and hypertension.
Area of Science:
- Pharmacology
- Clinical Therapeutics
Background:
- Loop diuretics are essential in managing fluid overload and hypertension.
- Furosemide is a widely used loop diuretic, but newer agents offer potential advantages.
Purpose of the Study:
- To review the clinical pharmacology of torsemide.
- To compare torsemide with existing loop diuretics, focusing on furosemide.
Main Methods:
- Literature search of MEDLINE (1985-1994) for pertinent studies.
- Evaluation and synthesis of data on torsemide's pharmacology, pharmacokinetics, and clinical use.
Main Results:
- Torsemide exhibits high bioavailability (~80%) and can be administered without regard to meals.
- It has a half-life of ~3.5 hours, with equivalent oral and IV efficacy.
- Torsemide is indicated for edema (heart failure, renal/hepatic disease) and hypertension, with once-daily dosing.
Conclusions:
- Torsemide is a pyridine-sulfonylurea loop diuretic with efficacy similar to furosemide.
- Its favorable pharmacokinetic profile supports once-daily dosing and equivalent therapeutic outcomes.