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Reference values of pulmonary diffusing capacity during exercise by a rebreathing technique

C C Hsia1, D G McBrayer, M Ramanathan

  • 1Department of Medicine, University of Texas Southwestern Medical Center, Dallas 75235-9034, USA.

American Journal of Respiratory and Critical Care Medicine
|August 1, 1995
PubMed
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Pulmonary diffusing capacity for carbon monoxide (DLCO), membrane diffusing capacity (DMCO), and pulmonary capillary blood volume (VC) increase with pulmonary blood flow (Qc). Qc is the primary factor influencing diffusing capacity recruitment during exercise.

Area of Science:

  • Pulmonary physiology
  • Respiratory medicine

Background:

  • Pulmonary diffusing capacity measurements are crucial for assessing lung function.
  • Establishing normal reference values and understanding determinants of diffusing capacity is essential for clinical interpretation.

Purpose of the Study:

  • To derive normal reference values for pulmonary diffusing capacity for carbon monoxide (DLCO), diffusing capacity of the membrane (DMCO), and pulmonary capillary blood volume (VC) using a rebreathing technique.
  • To investigate the relationship between these parameters and pulmonary blood flow (Qc), age, and body surface area (BSA) at rest and during exercise.

Main Methods:

  • A rebreathing technique was employed in 44 healthy, non-smoking individuals.
  • Measurements included DLCO, DMCO, VC, lung volumes, pulmonary blood flow (Qc), and septal tissue volume at rest and during incremental exercise.

Related Experiment Videos

  • Stepwise regression analysis was used to identify significant determinants of DLCO, DMCO, and VC.

    • Main Results:

    • DLCO and DMCO were significantly related to Qc, age, and BSA.
    • VC was significantly related to Qc and BSA.
    • Normalization for Qc and BSA reduced sex-based differences in measured parameters.
    • DLCO, DMCO, and VC increased linearly with Qc from rest to maximal exercise.

    Conclusions:

    • Pulmonary blood flow (Qc) is the most critical determinant of diffusing capacity recruitment.
    • DLCO, DMCO, and VC demonstrate a linear relationship with Qc during exercise, without reaching a plateau.