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Does mixed connective tissue disease exist in India?

A Sood1, A Kumar, I Pande

  • 1Department of Medicine, All India Institute of Medical Sciences, New Delhi.

British Journal of Rheumatology
|June 1, 1995
PubMed
Summary
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Mixed Connective Tissue Disease (MCTD) appears rare in India. A study screened 1000 patients, diagnosing only three with MCTD using standard criteria, suggesting low prevalence in the Indian population.

Area of Science:

  • Rheumatology
  • Immunology
  • Internal Medicine

Background:

  • Systemic connective tissue diseases encompass a range of autoimmune disorders.
  • Mixed Connective Tissue Disease (MCTD) is a distinct entity characterized by overlapping features of other connective tissue diseases.
  • Understanding the prevalence of MCTD in diverse populations is crucial for diagnosis and management.

Purpose of the Study:

  • To investigate the existence and prevalence of Mixed Connective Tissue Disease (MCTD) in the Indian population.
  • To screen a large cohort of patients with systemic connective tissue diseases for MCTD.

Main Methods:

  • Clinical and serological screening of 1000 consecutive patients with systemic connective tissue diseases.
  • Application of standard diagnostic criteria for MCTD.

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Main Results:

  • Only three out of 1000 screened patients met the diagnostic criteria for MCTD.
  • This indicates a low incidence of MCTD in the studied Indian population.

Conclusions:

  • Mixed Connective Tissue Disease (MCTD) is present in the Indian population.
  • However, MCTD appears to be a rare condition among Indians based on this study's findings.