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Related Experiment Videos

The immune response to trauma

B H Harris1, J A Gelfand

  • 1Division of Pediatric Surgery, Tufts University School of Medicine, Boston, MA, USA.

Seminars in Pediatric Surgery
|May 1, 1995
PubMed
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Trauma triggers an immediate immune response at the molecular level, involving inflammation and cytokine systems. This fundamental process, initiated by injury, can impact the entire body depending on severity and treatment.

Area of Science:

  • Immunology
  • Trauma Pathophysiology
  • Molecular Medicine

Background:

  • Inflammation was historically viewed as a response to external irritants.
  • Autoimmune diseases revealed inflammation as a self-directed response.
  • Trauma response adds a new dimension, highlighting inflammation as a fundamental life process.

Purpose of the Study:

  • To elucidate the initiation and progression of the inflammatory response to trauma.
  • To identify key molecular and cellular players in trauma-induced inflammation.
  • To understand trauma's impact on the systemic inflammatory response.

Main Methods:

  • Focus on the molecular and cellular events at the site of injury (wound, microcirculation).
  • Examination of immune cell activation (macrophages, endothelial cells).

Related Experiment Videos

  • Analysis of mediator production (proinflammatory cytokines).

    • Main Results:

    • Trauma initiates an immune response at the moment of injury, involving macrophages and endothelial cells.
    • Ischemia, impaired oxygen delivery, and necrotic tissue exacerbate inflammation.
    • Hemorrhage, sepsis, and soft tissue trauma converge on the cytokine system.

    Conclusions:

    • Inflammation is a fundamental life process initiated at the molecular level by trauma.
    • The cytokine system acts as a common pathway for various noxious stimuli.
    • The systemic inflammatory response (SIRS) can be initiated by trauma-induced cytokine release.