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The gelweave polyester arterial prosthesis

P Ukpabi¹, Y Marois, M King

¹Department of Surgery, Université Laval, Quebec.

Canadian Journal of Surgery. Journal Canadien De Chirurgie

|August 1, 1995

Summary

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The gelatin-sealed Gelweave prosthesis effectively seals, heals, and remains stable for arterial repair. This new vascular graft shows no adverse effects and is ready for clinical use.

Area of Science:

Biomaterials Science
Vascular Surgery
Regenerative Medicine

Background:

Woven polyester grafts are used as arterial prostheses.
Gelatin sealing aims to improve graft performance and reduce complications.

Purpose of the Study:

To evaluate the efficacy of Gelweave, a novel gelatin-sealed woven polyester arterial prosthesis.
To assess the impact of the gelatin coating on graft healing and biocompatibility.

Main Methods:

In vitro and in vivo studies were conducted using Gelweave in a canine thoracoabdominal bypass model.
Comparisons were made with unsealed precursor and collagen-coated prostheses.
Evaluated parameters included water permeability, healing, hematologic characteristics, and graft explant analysis.

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Main Results:

Gelweave demonstrated zero water permeability and no intraoperative blood loss or postoperative infection.
The gelatin coating was fully lysed within 2 weeks, promoting satisfactory graft healing and encapsulation without adverse reactions.
Low fibrin and platelet uptake and a favorable prostacyclin:thromboxane ratio were observed, indicating good biocompatibility.
The prosthesis maintained biostability for up to 6 months.

Conclusions:

The gelatin-sealed Gelweave arterial prosthesis is effective and biocompatible.
It exhibits satisfactory healing and biostability, making it suitable for clinical application.