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[Microcirculation and remodelling]

P G Camici1, R Lorenzoni

  • 1MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.

Cardiologia (Rome, Italy)
|December 1, 1994
PubMed
Summary
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Ventricular remodelling after myocardial infarction impacts coronary microcirculation, causing dysfunction even in remote areas. Positron emission tomography reveals impaired coronary reserve in patients with coronary artery disease and left ventricular hypertrophy.

Area of Science:

  • Cardiovascular Research
  • Myocardial Pathophysiology

Context:

  • Ventricular remodelling following acute myocardial infarction involves structural changes in myocytes, cardiac interstitium, and vascular walls.
  • Left ventricular hypertrophy, a form of remodelling, is associated with structural alterations in myocytes, interstitium, and coronary microcirculation (vascular remodelling).

Purpose:

  • To investigate microcirculatory dysfunction in patients with left ventricular hypertrophy and coronary artery disease using positron emission tomography (PET).
  • To evaluate myocardial blood flow and coronary reserve to assess the functional impact of structural changes in the coronary microcirculation.

Summary:

  • Positron emission tomography (PET) studies reveal microcirculatory alterations in patients with coronary artery disease (CAD), even without significant left ventricular hypertrophy.

Related Experiment Videos

  • Coronary vasodilator capacity is impaired post-myocardial infarction, affecting both infarcted and remote areas with normal-appearing vessels.
  • Blunted coronary reserve is detected in remote regions of ischemia in patients with stable angina and single-vessel CAD.

    • Impact:

    • Identifies microcirculatory dysfunction as a functional consequence of structural remodelling in cardiovascular diseases.
    • Highlights the utility of PET in noninvasively quantifying myocardial blood flow and coronary reserve for diagnosing and understanding cardiovascular conditions.
    • Suggests that impaired coronary reserve in remote areas is a significant finding in CAD, irrespective of hypertrophy.