Related Experiment Video
Updated: Aug 8, 2026

Acute Myocardial Infarction in Rats
Published on: February 16, 2011
[Evolution of myocardial ischemia therapy: calcium antagonists and ACE-inhibitors]
1Cattedra di Cardiologia, Università degli Studi, Brescia.
Abstract:
We have considered the possibility that the association between Ca(2+)-antagonists and ACE-inhibitors may be useful to treat patients with myocardial infarction. The two classes of drugs have synergic and complementary effects in terms of mechanism and site of action and of cardioprotective properties. In clinical trials Ca(2+)-antagonists failed to improve prognosis of patients with myocardial infarction, except verapamil which reduces mortality in patients with myocardial infarction and without pulmonary congestion. ACE-inhibitors are effective only in patients with myocardial infarction and congestive heart failure. Thus the two classes of drugs could be useful to treat patients with myocardial infarction but this hypothesis has to be confirmed with properly designed clinical trials.
More Related Videos
05:41Left Anterior Descending Coronary Artery Ligation for Ischemia-Reperfusion Research: Model Improvement via Technical Modifications and Quality Control
Published on: December 16, 2022
07:40Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy
Published on: May 26, 2023
Related Concept Videos
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
Antianginal Drugs: Calcium Channel Blockers and Ranolazine
CCBs, a diverse class that includes dihydropyridines (nifedipine) and diphenylalkylamines (verapamil and diltiazem), exert their effect by blocking calcium channels in cardiac and smooth muscle cells. This...
Coronary Artery Disease V: Interprofessional Care
Acute Coronary Syndrome IV: Interprofessional Care
Angina IV: Management
Cardiomyopathy V: Interprofessional Care