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Extraskeletal chondroma with chondroblastic and granuloma-like elements

T Yamada1, T Irisa, S Nakano

  • 1Department of Pathology, Saga Medical School, Japan.

Clinical Orthopaedics and Related Research
|June 1, 1995
PubMed
Summary

This case report details an extraskeletal chondroma in a man's finger. The rare tumor exhibited chondroid, granuloma-like, and chondroblastic zones with calcification and specific immunohistochemical markers.

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Area of Science:

  • Orthopedic Pathology
  • Soft Tissue Tumors
  • Skeletal System Neoplasms

Background:

  • Extraskeletal chondromas are rare benign cartilaginous tumors.
  • They can occur in various soft tissues, presenting diagnostic challenges.
  • Accurate diagnosis is crucial for appropriate management and prognosis.

Observation:

  • A unique case of extraskeletal chondroma in the right ring finger of a 51-year-old male patient is presented.
  • The tumor measured 4.0 x 2.2 x 1.5 cm and displayed distinct chondroid, granuloma-like, and chondroblastic cellular areas.
  • Fine calcification was noted within the tumor.

Findings:

  • Immunohistochemical analysis revealed vimentin positivity in most tumor cells (excluding multinucleated giant cells).
  • S-100 protein was positive in scattered tumor cells.

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  • Alpha-1 antichymotrypsin was observed in the chondroblastic and granuloma-like zones.
  • Ultrastructural examination showed a characteristic microvillous cell border in chondroblastic cells.

    • Implications:

    • This case expands the known spectrum of extraskeletal chondroma presentations.
    • The distinct histological and immunohistochemical profile aids in accurate diagnosis.
    • Further research into the cellular origins and behavior of such tumors is warranted.