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Related Experiment Videos

Methylene blue increases myocardial function in septic shock

C R Daemen-Gubbels1, P H Groeneveld, A B Groeneveld

  • 1Department of Internal Medicine, Medical Center Alkmaar, The Netherlands.

Critical Care Medicine
|August 1, 1995
PubMed
Summary
This summary is machine-generated.

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Methylene blue, an inhibitor of nitric oxide action, improved circulation in human septic shock patients. This study suggests nitric oxide plays a role in septic shock

Area of Science:

  • Cardiovascular Physiology
  • Critical Care Medicine
  • Pharmacology

Background:

  • Septic shock is characterized by circulatory dysfunction.
  • The role of nitric oxide (NO) in mediating these changes is not fully understood.

Purpose of the Study:

  • To investigate if nitric oxide mediates circulatory changes in human septic shock.
  • To evaluate the effects of methylene blue, an NO inhibitor, on hemodynamics.

Main Methods:

  • An open-label, nonrandomized clinical trial was conducted.
  • Nine patients with septic shock received a single dose of methylene blue.
  • Hemodynamic and metabolic variables were measured before and after the intervention.

Main Results:

Related Experiment Videos

  • Methylene blue increased mean arterial pressure and cardiac index.
  • Systemic vascular resistance increased, and arterial compliance decreased.
  • Oxygen delivery and uptake were significantly enhanced.

    • Conclusions:

    • Methylene blue transiently improved circulatory function in septic shock.
    • These findings suggest nitric oxide is a key mediator of circulatory changes in human septic shock.