Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

KL-6: a serum marker for interstitial pneumonia

J Kobayashi1, S Kitamura

  • 1Department of Pulmonary Medicine, Jichi Medical School, Tochigi, Japan.

Chest
|August 1, 1995
PubMed
Summary

KL-6 is a valuable biomarker for diagnosing pneumonitis. Elevated KL-6 levels indicate active pneumonitis, aiding in clinical assessment and disease activity evaluation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Daphnezomines F and G: novel alkaloids with 1-azabicyclo[5.2. 2]undecane moiety from Daphniphyllum humile.

The Journal of organic chemistry·2000
Same author

Cardiac transplantation under new legislation for organ transplantation in Japan: report of two cases.

Japanese circulation journal·2000
Same author

Correlation of anatomic and hemodynamic features with aortic valve leaflet deformity in doubly committed subarterial ventricular septal defect.

Heart and vessels·2000
Same author

Amphidinolide T, novel 19-membered macrolide from marine dinoflagellate Amphidinium sp.

The Journal of organic chemistry·2000
Same author

Oral granuloma associated with intestinal Behçet's disease.

The Journal of rheumatology·2000
Same author

An epidemiological survey on intestinal parasite infection in Khammouane Province, Lao PDR, with special reference to Strongyloides infection.

The Southeast Asian journal of tropical medicine and public health·2000

Area of Science:

  • Pulmonary Medicine
  • Biomarker Discovery
  • Clinical Diagnostics

Background:

  • KL-6, a mucinous glycoprotein on type 2 pneumonocytes, is elevated in interstitial pneumonia.
  • Its role in assessing pneumonitis activity requires further clarification.

Purpose of the Study:

  • To determine if KL-6 is a useful marker for pneumonitis activity.
  • To evaluate KL-6 levels in patients with and without pneumonitis.

Main Methods:

  • Measured KL-6 levels in 118 samples from 112 patients (51 with interstitial lung disease, 67 without).
  • Analyzed KL-6 levels in relation to pneumonitis presence and clinical activity.
  • Utilized receiver operating characteristic analysis to identify optimal cutoff values.

Main Results:

  • Significantly higher KL-6 levels in patients with pneumonitis (1,187 U/mL) versus those without (309 U/mL).
  • KL-6 levels were significantly higher in active pneumonitis (1,497 U/mL) compared to inactive pneumonitis (441 U/mL).
  • Optimal KL-6 cutoff for active pneumonitis ranged from 500 to 700 U/mL.

Conclusions:

  • KL-6 is a useful serum biomarker for diagnosing pneumonitis.
  • KL-6 effectively evaluates pneumonitis disease activity.
  • The findings support KL-6's role in clinical pneumonitis assessment.

Related Experiment Videos