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[Biological and molecular biology aspects of burn therapy]
P M Vogt1, D Hebebrand, J Hussmann
1Klinik für Plastische Chirurgie, Handchirurgie und Schwerbrandverletzte, BG-Kliniken Bergmannsheil, Ruhr-Universität Bochum.
Abstract:
Early wound closure, permanent skin replacement and management of postburn deformities are still unsolved problems in the treatment of burns. However, recent developments in biology and molecular biology provide new possibilities for improved therapy. This includes the enhancement of burn wound healing by growth factors and growth hormone, modulation of immunogenicity of skin allografts by gene transfer, cytokine treatment of burn sepsis and the use of cell membrane stabilizers in electrical injuries.