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Related Experiment Videos

Total serum calcium reference intervals in postmenopausal outpatients

M J Tanasijevic1, E Ginsburg, D R Wybenga

  • 1Department of Pathology and Clinical Laboratories, Brigham and Women's Hospital, Boston, Mass. 02115, USA.

Gynecologic and Obstetric Investigation
|January 1, 1995
PubMed
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Serum calcium levels are higher in postmenopausal women, suggesting a need for adjusted reference intervals. This study analyzed serum calcium in various adult groups to determine appropriate ranges for accurate diagnosis.

Area of Science:

  • Endocrinology
  • Clinical Chemistry
  • Gerontology

Background:

  • Serum calcium levels are critical for various physiological functions.
  • Established reference intervals for serum calcium may not adequately account for demographic variations.
  • Age and menopausal status can influence calcium homeostasis.

Purpose of the Study:

  • To investigate the distribution of serum calcium values in distinct outpatient populations.
  • To determine if current reference intervals for serum calcium are appropriate across different demographic groups.
  • To assess the impact of menopausal status and age on serum calcium levels.

Main Methods:

  • Serum calcium levels were measured in four groups: premenopausal women, postmenopausal women, men under 50, and men over 55.

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  • Average total serum calcium and reference intervals were calculated for each group.
  • Statistical comparisons were made between groups to identify significant differences.

    • Main Results:

    • Postmenopausal women exhibited significantly higher average total serum calcium (9.56 mg/dl) compared to premenopausal women (9.42 mg/dl) and older men (9.45 mg/dl).
    • A higher percentage of postmenopausal women (8%) had serum calcium levels above the current reference interval compared to premenopausal women (1.7%) and older men (3.3%).
    • Reference intervals for total serum calcium were established as 8.4-10.3 mg/dl for premenopausal women, 8.4-10.7 mg/dl for postmenopausal women, 8.6-10.5 mg/dl for younger men, and 8.4-10.4 mg/dl for older men.

    Conclusions:

    • Age-related increases in total serum calcium are evident in postmenopausal female outpatients.
    • The findings support the need for a higher upper limit in the reference interval for total serum calcium in postmenopausal women.
    • Adjusting reference intervals based on demographic factors like menopausal status can improve diagnostic accuracy.