Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

New cardiac drugs

M Kikura1, J H Levy

  • 1Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Japan.

International Anesthesiology Clinics
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Positive inotropic agents, including beta-adrenergic agonists and PDE III inhibitors, are crucial for treating acute heart failure. Understanding their mechanisms and clinical use improves patient outcomes in critical care settings.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Incorporating the concept of overtransfusion into hemovigilance monitoring: An expert-based definition and criteria from the International HIT-OVER Forum.

Transfusion·2024
Same author

Differential diagnoses for sepsis-induced disseminated intravascular coagulation: communication from the SSC of the ISTH.

Journal of thrombosis and haemostasis : JTH·2019
Same author

Derangement of the endothelial glycocalyx in sepsis.

Journal of thrombosis and haemostasis : JTH·2018
Same author

Sugammadex hypersensitivity and underlying mechanisms: a randomised study of healthy non-anaesthetised volunteers.

British journal of anaesthesia·2018
Same author

Use of factor concentrates for the management of perioperative bleeding: reply.

Journal of thrombosis and haemostasis : JTH·2018
Same author

Supplementary fibrinogen in the management of bleeding: re-evaluation of data from clinical trials.

British journal of anaesthesia·2018
Same journal

Regional Anesthesia for Hip Fracture Surgery in Frail Adults: Primary Anesthetic and Perioperative Analgesic Approaches.

International anesthesiology clinics·2026
Same journal

The Transition of Total Joint Arthroplasty From Inpatient to Ambulatory Surgery Centers: Evolution, Evidence, and Implications.

International anesthesiology clinics·2026
Same journal

Patient Blood Management in Orthopedic Surgery.

International anesthesiology clinics·2026
Same journal

The Practitioner's Guide to Upper Extremity Nerve Blocks.

International anesthesiology clinics·2026
Same journal

Anesthetic Challenges and Strategies in Pediatric Spine Surgery.

International anesthesiology clinics·2026
Same journal

Development of a Preoperative Physical Frailty-associated Screening Process: A Quality Improvement Initiative.

International anesthesiology clinics·2026
See all related articles

Area of Science:

  • Pharmacology
  • Cardiology
  • Critical Care Medicine

Background:

  • Positive inotropic agents are vital for managing acute heart failure.
  • Beta-adrenergic receptor agonists and phosphodiesterase III (PDE III) inhibitors represent key drug classes.

Purpose of the Study:

  • To review the mechanisms of action, pharmacology, and clinical applications of positive inotropic agents.
  • To highlight the roles of new cardiotonic drugs in perioperative and congestive heart failure.
  • To emphasize the importance of understanding PDE III inhibitors as inodilators.

Main Methods:

  • Literature review of positive inotropic agents.
  • Analysis of pharmacological properties and clinical efficacy.
  • Discussion of specific drugs like dopexamine, dobutamine, amrinone, milrinone, enoximone, and nicardipine.

Related Experiment Videos

Main Results:

  • Beta-adrenergic agonists (e.g., dopexamine, dobutamine) and PDE III inhibitors (e.g., amrinone, milrinone, enoximone) are effective in acute heart failure.
  • PDE III inhibitors act as inodilators, improving cardiac function and vasodilation.
  • Intravenous nicardipine offers arterial-specific vasodilation for perioperative hypertension.

Conclusions:

  • Positive inotropic agents are essential for managing acute cardiac conditions.
  • Appropriate use of these drugs, particularly PDE III inhibitors, is critical for effective treatment.
  • Newer agents provide valuable therapeutic options for perioperative cardiovascular support.