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Related Experiment Videos

Radiation-induced premature menopause: a misconception

B L Madsen1, L Giudice, S S Donaldson

  • 1Department of Radiation Oncology, Stanford University Medical Center, CA, USA.

International Journal of Radiation Oncology, Biology, Physics
|July 30, 1995
PubMed
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Women treated for Hodgkin's Disease with radiation fields excluding the pelvis have a low risk of premature menopause. Ovarian failure in these patients may stem from other causes, such as autoimmune disorders.

Area of Science:

  • Oncology
  • Reproductive Endocrinology
  • Radiation Oncology

Background:

  • Subtotal lymphoid irradiation is a treatment for Hodgkin's Disease.
  • Concerns exist regarding radiation-induced premature menopause in women treated with irradiation fields that exclude the pelvis.

Observation:

  • This study reviewed 36 women under age 50 diagnosed with Stage I or II supradiaphragmatic Hodgkin's Disease treated with subtotal lymphoid irradiation.
  • The mean follow-up was 14 years, with scatter radiation to the ovaries calculated at 3.2 Gy.
  • One woman (2.7%) experienced premature menopause, a rate not significantly different from the general population.

Findings:

  • Radiation fields excluding the pelvis pose little risk for premature menopause.
  • Fertility was preserved in most women, with 38 pregnancies resulting in normal offspring.

Related Experiment Videos

  • A case of premature ovarian failure potentially linked to an autoimmune syndrome associated with prior thyroid radiation is presented.

    • Implications:

    • Women experiencing premature menopause after treatment should be evaluated for autoimmune causes.
    • Treatment protocols for Hodgkin's Disease should consider the long-term reproductive health of female patients.