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Minocycline-induced hyperpigmentation
P H Hung1, J B Caldwell, W D James
1Pentagon Army Health Clinic, Washington, DC, USA.
The Journal of Family Practice
|August 1, 1995
Summary
Minocycline therapy can cause skin and nail hyperpigmentation, a rare side effect. While often reversible, permanent tooth discoloration may occur after long-term minocycline use for acne rosacea.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Minocycline is a commonly prescribed antibiotic for acne vulgaris and rosacea.
- Hyperpigmentation is an uncommon but recognized side effect of minocycline therapy.
Observation:
- A 70-year-old male patient presented with hyperpigmentation affecting forearms, hands, nails, sclerae, ears, and teeth.
- This occurred after 9 years of continuous minocycline treatment for acne rosacea.
Findings:
- Minocycline-induced hyperpigmentation is not typically dose-dependent.
- The condition usually resolves after discontinuing minocycline, though tooth discoloration may be permanent.
Implications:
- Clinicians should be aware of the potential for minocycline-induced hyperpigmentation.
- Patient counseling regarding the risk of permanent tooth discoloration is crucial for long-term therapy.