UV-inactivated measles virus stimulates human and mice naive lymphocytes to proliferate in vitro

Ultra violet (UV) light-inactivated measles virus was used for the lymphocyte proliferation assay, where it caused consistently adult human peripheral blood monolymphocytes (PBML) proliferation which was not dependent on the measles virus complement fixation titre in the donor's sera. When the cord blood lymphocytes from newborn baby and spleen lymphocytes from unprimed Balb/c, C57bl and CBA mice were used in the proliferation assay, all the lymphocytes were stimulated by the UV-inactivated measles virus in a dose-dependent manner. These results suggest that: (1) lymphotropic measles virus can also activate lymphocytes in vitro, and (2) this activation appeared to be neither species- nor major histocompatibility complex (MHC)-restricted. These results may have important implications for measles vaccination and the understanding of the immunopathogenesis of measles virus infection.