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Pyoderma gangraenosum caused by Rhizopus arrhizus

W Q Liao1, Z R Yao, Z Q Li

  • 1Department of Dermatology, Chang Zheng Hospital, Shanghai, China.

Mycoses
|January 1, 1995
PubMed
Summary

A rare case of pyoderma gangrenosum caused by Rhizopus arrhizus infection in a farmer was reported. The fungal infection of the arm was successfully treated with itraconazole.

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Area of Science:

  • Mycology
  • Dermatology
  • Infectious Diseases

Background:

  • Pyoderma gangrenosum (PG) is a rare, ulcerative neutrophilic dermatosis.
  • Fungal infections can sometimes mimic or trigger PG.
  • Rhizopus arrhizus is an opportunistic fungus, rarely implicated in cutaneous infections.

Observation:

  • A 50-year-old male farmer presented with a 2-month history of a painful, gangrenous, and festering lesion on his right upper arm.
  • The lesion exhibited central dry gangrene and a deeply ulcerated periphery with purulent discharge.
  • Histopathology confirmed a fungal infection involving the skin, muscle, and vessels.

Findings:

  • The causative fungus was isolated and identified as Rhizopus arrhizus.
  • This represents a rare instance of Rhizopus arrhizus causing pyoderma gangrenosum-like lesions.
  • The patient's infection demonstrated a positive response to antifungal therapy.

Implications:

  • Highlights the importance of considering rare fungal pathogens in refractory ulcerative skin conditions.
  • Suggests Rhizopus arrhizus as a potential, albeit uncommon, cause of infectious gangrenous ulcers.
  • Underscores the efficacy of systemic antifungal treatment, such as itraconazole, in managing such infections.

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