Related Experiment Videos
Bone mass in non-insulin-dependent diabetes mellitus
U Rishaug1, K I Birkeland, J A Falch
1Hormone Laboratory, Aker Hospital, Oslo, Norway.
Summary
Type 2 diabetes may be linked to higher bone mass, especially in women where body mass, not insulin levels, significantly impacts bone mineral density. This study explored bone density in diabetic patients compared to controls.
Area of Science:
- Endocrinology
- Metabolic Disorders
- Bone Metabolism
Background:
- Conflicting reports exist on bone mass in non-insulin-dependent diabetes.
- Type 2 diabetes mellitus (T2DM) affects various body systems, including bone health.
Purpose of the Study:
- To investigate bone mass in type 2 diabetic patients.
- To explore the relationship between metabolic parameters and bone mass in T2DM.
Main Methods:
- Dual X-ray absorptiometry and calcaneal ultrasound were used to measure bone mass.
- 36 type 2 diabetic subjects (21 men, 15 postmenopausal women) and matched controls were studied.
- Correlation and multiple regression analyses examined relationships between metabolic parameters and bone density.
Main Results:
- Diabetic subjects showed a tendency towards higher bone mass than controls.
- In diabetic postmenopausal women, fat and lean body mass positively correlated with bone mineral density (BMD) and bone mineral content (BMC).
- Insulin sensitivity negatively correlated with BMC and BMD, but this became non-significant when controlling for body mass, suggesting body mass is a key determinant.
Conclusions:
- Body mass is a more significant determinant of bone mineral density than hyperinsulinemia or insulin resistance in diabetic women.
- Lean body mass and serum oestrone/insulin levels showed correlations with bone parameters in diabetic men.