Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adrenocortical cytopathology

H Sasano1, S Shizawa, H Nagura

  • 1Department of Pathology, Tohoku University School of Medicine, Sendai, Japan.

American Journal of Clinical Pathology
|August 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantitative-analysis of immunohistochemical androgen receptor and ki-67 in prostatic-carcinoma and its relationship to histologic grade.

Oncology reports·2011
Same author

Intraepithelial CD8+ T-cell-count becomes a prognostic factor after a longer follow-up period in human colorectal carcinoma: possible association with suppression of micrometastasis.

British journal of cancer·2004
Same author

Interleukin-1beta increases RANTES gene expression and production in synovial fibroblasts from human temporomandibular joint.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·2004
Same author

Expression of somatostatin type 2A receptor correlates with estrogen receptor in human breast carcinoma.

Endocrine pathology·2004
Same author

Differential expression of cornified cell envelope precursors in normal skin, intraorally transplanted skin and normal oral mucosa.

The British journal of dermatology·2003
Same author

Nerve sheath myxoma of the tongue in a child.

International journal of oral and maxillofacial surgery·2002

Diagnosing adrenal cortex disorders like adenomas and carcinomas can be challenging. Immunocytochemistry for Ad4BP aids in differentiating these tumors and ruling out renal cell carcinoma.

Area of Science:

  • Endocrinology
  • Cytopathology
  • Oncology

Background:

  • Adrenal cortex disorders, including nodules, adenomas, and carcinomas, present diagnostic challenges.
  • Cytologic evaluation of these conditions is complicated by intra-tumoral heterogeneity.

Purpose of the Study:

  • To evaluate the utility of cytopathology and immunocytochemistry in diagnosing human adrenal cortex disorders.
  • To differentiate between adrenocortical adenoma, adrenocortical carcinoma, and renal cell carcinoma.

Main Methods:

  • Cytopathologic smears and imprints from 9 cases of normal adrenal cortex and various disorders were analyzed.
  • Immunocytochemistry was performed targeting 3 beta-hydroxysteroid dehydrogenase and adrenal-4-binding protein (Ad4BP).

Main Results:

Related Experiment Videos

  • No cytologic differences were found between normal adrenal cortex and adrenocortical nodules.
  • Large nuclei with prominent nucleoli were characteristic of adrenocortical neoplasms.
  • Cellular atypia and cohesiveness were unreliable for differentiating adenoma from carcinoma; mitosis and necrosis were seen only in carcinoma.
  • Cytologic criteria alone were insufficient for definitive diagnosis due to heterogeneity.
  • Cytologic differentiation between adrenocortical and renal cell carcinoma was unreliable.
  • Ad4BP immunocytochemistry significantly aided in differentiating adrenocortical tumors from renal cell carcinoma.

Conclusions:

  • Cytologic features alone are insufficient for accurately diagnosing adrenal cortex disorders.
  • Immunocytochemistry, particularly for Ad4BP, is a valuable tool for differential diagnosis of adrenocortical neoplasms and distinguishing them from renal cell carcinoma.