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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Menopause01:28

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Infertility in Males01:23

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...

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Related Experiment Video

Updated: Jun 12, 2026

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

Severe osteoporosis in men

N Kelepouris1, K D Harper, F Gannon

  • 1Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia 19104-6149, USA.

Annals of Internal Medicine
|September 15, 1995
PubMed
Summary
This summary is machine-generated.

Severe osteoporosis in men often has identifiable causes, though some cases are primary. Further research is needed to understand male osteoporosis and develop treatments.

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Last Updated: Jun 12, 2026

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
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Area of Science:

  • Endocrinology
  • Metabolic Bone Disease
  • Men's Health

Background:

  • Osteoporosis is a significant health concern, particularly in men, where it can lead to severe fractures.
  • Identifying underlying causes of osteoporosis in men is crucial for effective management and treatment.

Purpose of the Study:

  • To investigate the pathogenetic factors contributing to severe osteoporosis in men.
  • To review the characteristics of primary osteoporosis in the male population.

Main Methods:

  • A case series and clinical review involving 47 men referred for severe osteoporosis.
  • Utilized clinical assessments, imaging, biochemical analyses, hormone assays, bone densitometry, and iliac crest biopsy.

Main Results:

  • Over half of the men experienced vertebral fractures, and a third had appendicular fractures.
  • Identifiable causes were found in 64% of men, including glucocorticosteroid use, hypogonadism, and alcohol abuse.
  • Primary osteoporosis, characterized by reduced bone density and altered bone histology, was observed in a subset of patients.

Conclusions:

  • A comprehensive evaluation for secondary causes of severe osteoporosis in men is essential.
  • Primary osteoporosis in men likely results from multifactorial influences, necessitating further research into its mechanisms and treatment strategies.