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Eosinophilic vasculitis syndrome: recurrent cutaneous eosinophilic necrotizing vasculitis
K R Chen1, W P Su, M R Pittelkow
1Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA.
Seminars in Dermatology
|June 1, 1995
Summary
A new syndrome of recurrent cutaneous eosinophilic vasculitis was identified in three patients. This distinct skin condition features itchy, swollen lesions and responds to steroid treatment.
Area of Science:
- Dermatology
- Immunology
- Pathology
Background:
- Recurrent cutaneous eosinophilic vasculitis is a rare condition.
- Distinctive clinical and histopathological features are key to diagnosis.
Purpose of the Study:
- To identify and characterize a distinct syndrome of recurrent cutaneous eosinophilic vasculitis.
- To differentiate this entity from other vasculitic disorders.
Main Methods:
- Clinical observation of three patients with recurrent skin lesions.
- Skin biopsies analyzed for histopathological features and immunofluorescence.
- Peripheral blood eosinophilia and serum cytokine analysis.
Main Results:
- Patients presented with pruritic, erythematous, purpuric papules and angioedema.
- Skin biopsies revealed necrotizing vasculitis with eosinophilic infiltration.
- Disease followed a chronic course, responding to systemic steroids.
- Eosinophil granule major basic protein deposition and IL-5 detected.
Conclusions:
- A distinct syndrome of recurrent cutaneous eosinophilic vasculitis is identified.
- Characterized by specific clinical and histopathological findings.
- This entity should be distinguished from other vasculitides.