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Olmsted syndrome

H O Perry1, W P Su

  • 1Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA.

Seminars in Dermatology
|June 1, 1995
PubMed
Summary
This summary is machine-generated.

Olmsted syndrome is a rare condition causing thick, symmetrical keratoderma on palms and soles, often starting in infancy. It can lead to finger contraction, foot fissuring, and affects body orifices, requiring differential diagnosis.

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Area of Science:

  • Dermatology
  • Clinical Genetics

Background:

  • Olmsted syndrome is an extremely rare genodermatosis.
  • It is characterized by progressive, symmetrical keratoderma and affects various body parts.

Purpose of the Study:

  • To describe the clinical manifestations and progression of Olmsted syndrome.
  • To highlight the importance of considering Olmsted syndrome in the differential diagnosis of keratoderma.

Main Methods:

  • Literature review of reported cases of Olmsted syndrome.
  • Clinical description based on nine documented cases.

Main Results:

  • Keratoderma typically begins in infancy on palms and soles, progressing symmetrically.
  • Complications include digital contractures, pedal fissuring, and involvement of periorificial areas.

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  • Associated symptoms may include alopecia, nail dystrophy, and oral leukokeratosis.
  • Conclusions:

    • Olmsted syndrome presents with distinctive hyperkeratotic plaques and papules.
    • Early recognition is crucial for managing complications and differentiating from other keratoderma syndromes.