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POEMS syndrome

C Perniciaro1

  • 1Department of Dermatology, Mayo Clinic Jacksonville, FL 32224, USA.

Seminars in Dermatology
|June 1, 1995
PubMed
Summary
This summary is machine-generated.

POEMS syndrome, a rare disorder, involves bone lesions, neuropathy, and abnormal proteins. Skin manifestations like hyperpigmentation and unique hemangiomas are common in affected individuals.

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Area of Science:

  • Endocrinology and Metabolism
  • Neurology
  • Dermatology

Background:

  • POEMS syndrome is a rare multisystem disorder characterized by osteosclerotic lesions, peripheral neuropathy, and monoclonal gammopathy.
  • Cutaneous manifestations are frequently observed in POEMS syndrome, impacting patient diagnosis and management.

Purpose of the Study:

  • To summarize the key clinical features of POEMS syndrome, with a focus on dermatological findings.
  • To highlight the diagnostic significance of specific skin lesions in POEMS syndrome.

Main Methods:

  • Review of clinical features associated with POEMS syndrome.
  • Analysis of the prevalence and characteristics of skin lesions in patients.

Main Results:

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  • The principal features include osteosclerotic bone lesions, sensorimotor neuropathy, and monoclonal protein elevation.
  • Skin lesions are present in most patients, with diffuse hyperpigmentation being the most common finding.
  • Hemangiomas with glomeruloid features are identified as the most specific cutaneous marker for POEMS syndrome.

    • Conclusions:

    • POEMS syndrome presents with a distinct constellation of systemic and dermatological findings.
    • The presence of specific skin lesions, such as glomeruloid hemangiomas, can aid in the early diagnosis of POEMS syndrome.