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Sneddon syndrome

M S Daoud1, G J Wilmoth, W P Su

  • 1Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA.

Seminars in Dermatology
|June 1, 1995
PubMed
Summary
This summary is machine-generated.

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Sneddon syndrome is a rare cerebrovascular disorder causing skin lesions and neurological issues. While no cure exists, antiplatelet or antithrombotic drugs may help manage its progression.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Dermatology

Background:

  • Sneddon syndrome, first described in 1965, is a rare condition characterized by livedo racemosa and central nervous system (CNS) ischemia.
  • It is a progressive disorder affecting small and medium-sized arteries, primarily in the skin and brain.

Purpose of the Study:

  • To review the clinical and pathological features of Sneddon syndrome.
  • To discuss potential therapeutic strategies for managing this uncommon disorder.

Main Methods:

  • Review of existing literature on Sneddon syndrome.
  • Analysis of clinical manifestations and histopathological findings.

Main Results:

  • Sneddon syndrome presents with generalized livedo racemosa and neurological deficits due to cerebrovascular lesions.

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  • Histopathology reveals intimal endothelial proliferation and fibromucinous matrix formation, leading to vessel obstruction.
  • The disease follows a slowly progressive course.

    • Conclusions:

    • Sneddon syndrome is a distinct vasculopathy with significant neurological and cutaneous manifestations.
    • Currently, no definitive treatment is available, but anticoagulation and antiplatelet therapies show potential in mitigating disease progression and complications.