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Bazex syndrome: acrokeratosis paraneoplastica
1Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520, USA.
Seminars in Dermatology
|June 1, 1995
Summary
Bazex syndrome, or acrokeratosis paraneoplastica, often presents with psoriasiform skin lesions preceding cancer diagnosis. These cutaneous manifestations typically improve with cancer treatment, highlighting their paraneoplastic nature.
Area of Science:
- Dermatology
- Oncology
- Paraneoplastic Syndromes
Background:
- Bazex syndrome, specifically acrokeratosis paraneoplastica, is a rare disorder associated with underlying neoplasms.
- Squamous cell carcinoma of the upper aerodigestive tract is the most common associated malignancy.
Purpose of the Study:
- To review cases of acrokeratosis paraneoplastica to understand the relationship between cutaneous manifestations and neoplasm diagnosis.
- To emphasize the importance of recognizing Bazex syndrome's dermatological signs for early cancer detection.
Main Methods:
- Systematic review of 113 reported cases of acrokeratosis paraneoplastica.
- Analysis of the temporal relationship between skin lesion onset and malignancy diagnosis.
- Evaluation of skin lesion response to cancer treatment.
Main Results:
- In 67% of cases, psoriasiform lesions preceded cancer diagnosis.
- In 15% of cases, skin lesions followed cancer diagnosis; others were simultaneous.
- Skin lesions resolved or improved with neoplasm treatment in 93% of cases, indicating a paraneoplastic etiology.
Conclusions:
- Acrokeratosis paraneoplastica (Bazex syndrome) is a significant indicator of underlying malignancy, often preceding diagnosis.
- Dermatologists must be aware of these cutaneous signs for timely cancer detection and management.
- Resolution of skin lesions with cancer treatment further supports the paraneoplastic nature of Bazex syndrome.