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Extensive cutaneous lymphoma

D Laky1, D Rădulescu

  • 1Victor Babes Institute, Surgery Department of the Cantacuzino Hospital, Bucharest, Romania.

Romanian Journal of Morphology and Embryology = Revue Roumaine De Morphologie Et Embryologie
|January 1, 1994
PubMed
Summary
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A rare B-cell lymphoma case is detailed, involving a patient with a large, painless cervical tumor. Histopathology confirmed polymorphous centroblastic malignant lymphoma, a type of non-Hodgkin lymphoma.

Area of Science:

  • Oncology
  • Dermatopathology
  • Immunohistochemistry

Background:

  • Subcutaneous tumors require accurate diagnosis for effective treatment.
  • Malignant lymphomas can present as unusual skin lesions.

Observation:

  • A 35-year-old patient presented with a large, progressive, painless subcutaneous tumor in the right cervical region.
  • The tumor was pale brown/red, without adherence to skin or muscles, and the patient was asymptomatic.

Findings:

  • Histopathology revealed dermal infiltration by small, round/oval hyperchromatic cells.
  • Histoenzymology showed positive CLA and MB2 markers (leukocytic origin).
  • L26 reaction confirmed B-cell origin, diagnosing polymorphous centroblastic malignant lymphoma (K type Working Classification).

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Implications:

  • This case highlights the importance of thorough histopathological and immunohistochemical analysis for diagnosing rare cutaneous lymphomas.
  • Accurate classification is crucial for determining appropriate therapeutic strategies in non-Hodgkin lymphoma.
  • Understanding the presentation of cutaneous B-cell lymphomas aids in early detection and management.