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[Clinical study of improving effect of shuxinyin on abnormal left ventricular diastolic function in coronary heart

W Chen1, Y He, Z X Lin

  • 1Longhua Hospital, Shanghai University of TCM.

Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine
|May 1, 1995
PubMed

Insights

Shuxinyin (SXY) therapy improved early left ventricular diastolic function in coronary heart disease patients. This traditional Chinese medicine treatment alleviated symptoms and improved echocardiographic measures of diastolic filling.

Area of Science:

  • Cardiology
  • Traditional Chinese Medicine
  • Cardiovascular Research

Background:

  • Abnormal left ventricular diastolic function is prevalent in coronary heart disease (CHD), leading to symptoms like dyspnea and chest distress, potentially progressing to heart failure.
  • Pulsed Doppler echocardiography is a key tool for assessing left ventricular diastolic function.
  • Traditional Chinese Medicine (TCM) offers potential therapeutic avenues for cardiovascular conditions.

Purpose of the Study:

  • To investigate the effects of Shuxinyin (SXY), a TCM herbal formula, on left ventricular diastolic function in patients with CHD.
  • To evaluate the impact of SXY therapy on clinical symptoms, electrocardiographic findings, and plasma lipoprotein levels.
  • To assess changes in Doppler echocardiographic parameters indicative of diastolic function.

Main Methods:

  • A study involving 31 patients diagnosed with coronary heart disease and abnormal left ventricular diastolic function.
  • Treatment administered: Shuxinyin (SXY), a herbal formula focused on tonifying Qi and Yin, for one month.
  • Assessment methods included clinical evaluation of symptoms and signs, electrocardiography (ECG), plasma lipoprotein analysis, and pulsed Doppler echocardiography.

Main Results:

  • SXY therapy resulted in significant improvement in clinical symptoms and ECG findings, with a symptomatic effective rate of 87.1%.
  • Plasma lipoprotein levels were significantly reduced (P < 0.05) after SXY treatment.
  • Doppler echocardiography revealed significant increases in the peak E wave, E wave area, and deceleration rate (P < 0.01), along with a decreased A/E wave peak ratio, indicating improved early diastolic function.

Conclusions:

  • Shuxinyin (SXY) effectively improves early left ventricular diastolic function in patients with coronary heart disease.
  • The therapy enhances peak velocity and volume of rapid left ventricular filling during early diastole.
  • SXY treatment alleviates clinical symptoms and improves ECG findings associated with diastolic dysfunction in CHD.

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