Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet-derived growth factor

W Meyer-Ingold1, W Eichner

  • 1Beiersdorf AG, Hamburg, Germany.

Cell Biology International
|May 1, 1995
PubMed
Summary
This summary is machine-generated.

Platelet-derived growth factor (PDGF) isoforms, including PDGF-AB, activate mesenchymal cells. This review highlights the challenges in producing PDGF-AB for in vivo studies, limiting available data compared to PDGF-BB.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Selective pick-up of increased iron by deferoxamine-coupled cellulose abrogates the iron-driven induction of matrix-degrading metalloproteinase 1 and lipid peroxidation in human dermal fibroblasts in vitro: a new dressing concept.

The Journal of investigative dermatology·2001
Same author

Large scale production of RH-albumin expressed in the milk of transgenic cattle--an economic and technical challenge.

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS·2000
Same author

Increased temperature: a potentially important side-effect of ultraviolet radiation treatment leading to induction of interstitial collagenase/matrix metalloproteinase-1.

The British journal of dermatology·1998
Same author

[A humid environment will propagate physiological wound healing].

Krankenpflege Journal·1998
Same author

Protease inhibitors protect growth factor activity in chronic wounds.

The British journal of dermatology·1997
Same author

Hydroactive dressings and serum proteins: an in vitro study.

Journal of wound care·1996
Same journal

Adipose-Derived Stem Cells Differentiate Into Insulin-Producing Cells in 2D Culture With Photobiomodulation: A Comparative Analysis of Wavelength and Fluence Parameters.

Cell biology international·2026
Same journal

Impaired Neurosphere Formation as a Functional Readout of Aberrant EGFR Signaling Kinetics in Olfactory Neural Progenitors From Patients With Schizophrenia.

Cell biology international·2026
Same journal

Mechanobiology-Driven Metabolic Reprogramming: Integrative Roles of YAP/TAZ Signaling and Extracellular Matrix Dynamics.

Cell biology international·2026
Same journal

NPC2 Regulates Glioblastoma Cholesterol Metabolism and Malignant Behavior via GPX4-Linked Ferroptosis.

Cell biology international·2026
Same journal

Icariin as a Modulator of Cancer Cell Biology: Integrated Control of Proliferation, Cell Death Programs, Metastasis Signaling, and Delivery Challenges.

Cell biology international·2026
Same journal

Temporal Lysophosphatidic Acid Supplementation Enhances Megakaryocyte Differentiation and Platelet Production From Human Hematopoietic Progenitors.

Cell biology international·2026
See all related articles

Area of Science:

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Background:

  • Platelet-derived growth factor (PDGF) activates mesenchymal cells.
  • Three PDGF isoforms exist: AA, BB, and AB homodimers and heterodimers.
  • PDGF-AA is the weakest cellular mitogen among the isoforms.

Purpose of the Study:

  • To review the biological activities of different PDGF isoforms.
  • To focus on the PDGF-AB heterodimer due to its complex expression and purification.
  • To highlight the limited in vivo data for PDGF-AB compared to PDGF-BB.

Main Methods:

  • Comparative studies of purified recombinant PDGF isoforms.
  • Review of existing literature on PDGF isoform activity and applications.
  • Analysis of heterologous gene expression and purification challenges for PDGF-AB.

Related Experiment Videos

Main Results:

  • All three PDGF isoforms (AA, BB, AB) show biological activity in vitro.
  • PDGF-AB presents significant challenges in heterologous gene expression and purification.
  • Limited in vivo application data exists for PDGF-AB compared to PDGF-BB.

Conclusions:

  • Understanding PDGF isoform-specific activities is crucial.
  • Advancements in expression and purification are needed for PDGF-AB in vivo studies.
  • Further research on PDGF-AB in vivo applications is warranted.