Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

6.3K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.3K
Insulin Secretory Vesicles01:05

Insulin Secretory Vesicles

6.3K
Insulin secretory vesicles release insulin to stimulate blood glucose uptake and regulate carbohydrate metabolism. When the blood glucose levels increase, glucose enters the pancreatic β-islet cells through glucose transporters. Once inside, glucose is metabolized through glycolysis, the citric acid cycle, and the electron transport chain, producing ATP. This increase in ATP concentration closes ATP-sensitive potassium channels, leading to depolarization of the membrane and the opening of...
6.3K
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

7.2K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.2K
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

3.9K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
3.9K
Insulin: The Receptor and Signaling Pathways01:28

Insulin: The Receptor and Signaling Pathways

6.0K
Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...
6.0K
Glucagon-like Receptor Agonists01:24

Glucagon-like Receptor Agonists

1.3K
Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A data-driven approach to determine the minimum number of spot samples for estimating methane and carbon dioxide emissions from Austrian dairy cows on commercial farms using GreenFeed.

Journal of dairy science·2026
Same author

dVP_FAM-development and evaluation of a transsectoral digital care platform for individuals with familial cancer risks: study protocol for a multi-centre, cluster-randomised, mixed-methods study.

Trials·2025
Same author

Incidence of neutrophil extracellular traps (NETs) in different membrane oxygenators: pilot in vitro experiments in commercially available coated membranes.

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs·2025
Same author

Predictive preoperative clinical score for patients with liver-only oligometastatic colorectal cancer.

ESMO open·2022
Same author

Mid-Term Outcomes of a Hybrid Approach Involving Open Surgery Plus TEVAR of the Descending Aorta in the Treatment of Complex Type A Dissection.

The Thoracic and cardiovascular surgeon·2022
Same author

Effects of temporal fine structure preservation on spatial hearing in bilateral cochlear implant users.

The Journal of the Acoustical Society of America·2021

Related Experiment Video

Updated: May 1, 2026

A Quantitative Assay for Insulin-expressing Colony-forming Progenitors
14:39

A Quantitative Assay for Insulin-expressing Colony-forming Progenitors

Published on: November 28, 2011

14.0K

Insulin-like growth factors

C Schmid1

  • 1Department of Medicine, University Hospital, Zurich, Switzerland.

Cell Biology International
|May 1, 1995
PubMed
Summary
This summary is machine-generated.

Insulin-like growth factors (IGFs) regulate cell growth and protein synthesis by signaling through specific receptors. These factors are crucial for bone growth, tissue repair, and maintaining cell survival throughout life.

More Related Videos

Development of a Multicellular Three-dimensional Organotypic Model of the Human Intestinal Mucosa Grown Under Microgravity
08:54

Development of a Multicellular Three-dimensional Organotypic Model of the Human Intestinal Mucosa Grown Under Microgravity

Published on: July 25, 2016

9.1K
Author Spotlight: Advancements and Challenges in β-Cells Differentiation from Pluripotent Stem Cells
06:33

Author Spotlight: Advancements and Challenges in β-Cells Differentiation from Pluripotent Stem Cells

Published on: February 2, 2024

2.7K

Related Experiment Videos

Last Updated: May 1, 2026

A Quantitative Assay for Insulin-expressing Colony-forming Progenitors
14:39

A Quantitative Assay for Insulin-expressing Colony-forming Progenitors

Published on: November 28, 2011

14.0K
Development of a Multicellular Three-dimensional Organotypic Model of the Human Intestinal Mucosa Grown Under Microgravity
08:54

Development of a Multicellular Three-dimensional Organotypic Model of the Human Intestinal Mucosa Grown Under Microgravity

Published on: July 25, 2016

9.1K
Author Spotlight: Advancements and Challenges in β-Cells Differentiation from Pluripotent Stem Cells
06:33

Author Spotlight: Advancements and Challenges in β-Cells Differentiation from Pluripotent Stem Cells

Published on: February 2, 2024

2.7K

Area of Science:

  • Endocrinology
  • Cell Biology
  • Biochemistry

Background:

  • Insulin-like growth factors (IGFs) I and II are homologous to proinsulin.
  • IGFs are vital for cell regulation, protein synthesis, and cellular signaling via type 1 receptors.

Purpose of the Study:

  • To elucidate the role of IGFs in cell regulation and bone growth.
  • To understand the mechanism of IGF action through type 1 receptors and phosphorylation cascades.
  • To explore the function of IGF binding proteins (IGFBPs) in modulating IGF activity.

Main Methods:

  • The study reviews existing literature on IGFs and their receptors.
  • Analysis of signaling pathways activated by IGFs, including phosphorylation cascades.
  • Examination of the role of IGFs in chondrocyte proliferation and endochondral bone growth.
  • Investigation of IGFBP functions in controlling IGF availability and activity.

Main Results:

  • IGFs stimulate protein synthesis and chondrocyte proliferation, promoting longitudinal bone growth.
  • IGFs are constitutively expressed, essential for differentiated cell survival, and upregulated during growth and tissue repair.
  • Six IGF binding proteins (IGFBP 1-6) provide tissue-specific control, with production favoring storage and cleavage leading to activation.

Conclusions:

  • IGFs are critical regulators of cell growth, differentiation, and tissue homeostasis.
  • The IGF system, including receptors and binding proteins, plays a multifaceted role in development and repair.
  • Understanding IGF signaling is key to comprehending fundamental biological processes.