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Related Experiment Videos

Quantitative contrast media dose evaluation for cranial computed tomography

G M Hammer1, M J Kuhn, D M Meis

  • 1Division of Neuroradiology, Southern Illinois University School of Medicine, Springfield 62769, USA.

Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society
|May 1, 1995
PubMed
Summary
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For contrast-enhanced cranial CT scans, 100 ml of ioversol provides optimal enhancement in key intracranial vessels. Doses of 100 ml and 120 ml showed no significant difference, suggesting a cost-effective optimal dose.

Area of Science:

  • Radiology and Imaging Science
  • Medical Contrast Agents
  • Neurovascular Imaging

Background:

  • Contrast-enhanced computed tomography (CT) is crucial for visualizing intracranial vasculature.
  • Optimizing contrast medium volume is essential for achieving diagnostic image quality while managing costs.
  • Ioversol 320 mg I/ml is a commonly used iodinated contrast agent for CT imaging.

Purpose of the Study:

  • To quantitatively assess CT enhancement of intracranial vessels with varying ioversol volumes.
  • To determine a cost-effective contrast dose for cranial CT examinations.
  • To compare enhancement levels between 50 ml, 75 ml, 100 ml, and 120 ml ioversol doses.

Main Methods:

  • Prospective, double-blind study involving 100 patients undergoing contrast-enhanced cranial CT.

Related Experiment Videos

  • Random assignment to receive 50, 75, 100, or 120 ml of ioversol 320 mg I/ml intravenously at 1 ml/s.
  • Hounsfield unit measurements were taken in the supraclinoid internal carotid arteries, basilar artery, and torcular region on pre- and post-contrast scans.

    • Main Results:

    • Mean enhancement values increased with contrast volume: LICA (29.9-64.6), RICA (30.1-65.1), BA (30.0-71.9), TR (31.7-74.3).
    • No statistically significant difference in enhancement was observed between 100 ml and 120 ml doses for any vessel.
    • A statistically significant improvement in enhancement was found with 100 ml compared to 75 ml across all evaluated vessels (p < 0.05).

    Conclusions:

    • 100 ml of ioversol 320 mg I/ml provides comparable enhancement to 120 ml for key intracranial vessels in CT.
    • The 100 ml dose represents a potentially cost-effective volume, achieving significant enhancement over lower doses.
    • This study supports the use of 100 ml ioversol for optimal and efficient neurovascular CT imaging.