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Synthesis of toddacoumaquinone, a coumarin-naphthoquinone dimer, and its antiviral activities
T Ishikawa1, K Kotake, H Ishii
1Faculty of Pharmaceutical Sciences, Chiba University, Japan.
Chemical & Pharmaceutical Bulletin
|June 1, 1995
Abstract:
Toddacoumaquinone (1), a coumarin-naphthoquinone dimer, was synthesized through Diels-Alder reaction between 8-(1-acetoxy-3-methyl-1,3-butadienyl)-5,7-dimethoxycoumarin (15) and 2-methoxy-1,4-benzoquinone (5). The activities of 1 against several viruses were examined. A weak activity (EC50 = 10 micrograms/ml) was observed against HSV-1 and HSV-2, but no activity was seen against HIV-1.