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Histomorphometric analysis of normal bone from the iliac crest
Acta Pathologica Et Microbiologica Scandinavica. Section A, Pathology
|January 1, 1978
Summary
Bone mass decreases with age in Danish adults. Osteoid and resorption parameters remain stable, except for reduced cortical bone resorption in older males, impacting metabolic bone disease diagnosis.
Area of Science:
- Bone Histomorphometry
- Skeletal Biology
- Aging Research
Background:
- Bone remodeling is crucial for skeletal health and integrity.
- Age-related changes in bone mass and microarchitecture are significant.
- Understanding normal bone parameters is essential for diagnosing metabolic bone diseases.
Purpose of the Study:
- To establish normal histomorphometric values for cancellous and cortical bone in a Danish population.
- To investigate age and sex-related variations in bone mass and remodeling parameters.
- To assess the diagnostic utility of histomorphometry in metabolic bone diseases.
Main Methods:
- Obtained iliac crest bone specimens from 105 autopsy cases and 30 living volunteers.
- Prepared 7-micron thick sections of plastic-embedded undecalcified bone.
- Utilized point counting and simple measurements for quantitative analysis.
Main Results:
- Bone mass (trabecular and cortical) decreased with age in both sexes.
- Osteoid seam extent, volume, and width were age-independent.
- Osteoclastic resorption was generally age-independent, with a decrease in cortical bone in males.
Conclusions:
- Established reference ranges for bone histomorphometry in a Danish population.
- Highlighted age-related bone loss and specific remodeling patterns.
- Emphasized the need for dynamic assessment (e.g., tetracycline labeling) for comprehensive understanding of bone pathogenesis.