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A case of lymphoblastic lymphoma with aberrant morphologic feature
N Nakamura1, K Tasaki, K Tominaga
1Department of Pathology I, Fukushima Medical College, Japan.
Fukushima Journal of Medical Science
|December 1, 1994
Summary
This study details a rare case of B-cell lymphoblastic lymphoma in a 33-year-old woman, presenting with unique features. The findings highlight a distinct subtype of lymphoma with implications for diagnosis and treatment.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- B-cell lymphoblastic lymphoma (B-LL) is an aggressive non-Hodgkin lymphoma.
- Burkitt's lymphoma (BL) is characterized by specific morphologic and genetic features.
- Distinguishing between B-LL and BL is crucial for appropriate patient management.
Observation:
- A 33-year-old Japanese female presented with bilateral breast involvement.
- Histopathology revealed lymphoblasts with lipid droplets, starry sky macrophages, and oval/indented nuclei.
- Immunophenotyping showed expression of TdT, CD10, CD14, CD38, and WH14.
Findings:
- Genetic analysis confirmed immunoglobulin heavy chain gene rearrangement and germline T-cell receptor and c-myc genes.
- The immunophenotype and genotype differed from typical BL but matched B-cell lymphoblastic lymphoma.
- The neoplasm was identified as B-cell lymphoblastic lymphoma with lipid droplet-containing lymphoblasts.
Implications:
- This case expands the known spectrum of B-cell lymphoblastic lymphoma.
- The presence of lipid droplets may represent a unique morphologic marker.
- Further research is needed to understand the clinical significance and therapeutic strategies for this specific lymphoma subtype.