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Construction and characterization of an isogenic urease-negative mutant of Helicobacter mustelae
J V Solnick1, C Josenhans, S Suerbaum
1Division of Infectious Diseases, University of California, Davis, School of Medicine, USA.
Infection and Immunity
|September 1, 1995
Abstract:
Helicobacter mustelae infects the ferret stomach and provides an opportunity to study pathogenic determinants of a Helicobacter species in its natural host. We constructed an isogenic urease-negative mutant of H. mustelae which produced no detectable urease and showed a reduced acid tolerance. This mutant provides an opportunity to further evaluate the role of urease in the pathogenesis of Helicobacter infection.