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Related Experiment Videos

[P-glycoprotein expression in hematological malignancies]

M Yamaguchi1, M Mizutani, H Miwa

  • 1Second Department of Internal Medicine, Mie University School of Medicine.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|June 1, 1995
PubMed
Summary

P-glycoprotein (P-gp) expression is common in T, NK cell, and stem cell malignancies. This finding helps understand chemotherapy resistance in hematological cancers.

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Area of Science:

  • Hematology
  • Molecular Biology
  • Oncology

Background:

  • P-glycoprotein (P-gp), encoded by the MDR1 gene, is a transmembrane efflux pump.
  • P-gp expression is implicated in multidrug resistance (MDR) in various cancers.
  • Understanding P-gp expression in hematological malignancies is crucial for optimizing chemotherapy.

Purpose of the Study:

  • To investigate common characteristics of P-gp expressing hematological malignancies.
  • To determine if chemotherapy induces P-gp expression.
  • To analyze P-gp/MDR1 expression in different subtypes of leukemia and lymphoid malignancies.

Main Methods:

  • Analysis of P-gp/MDR1 expression in tumor cells from 200 Japanese patients.
  • Functional P-gp expression assessed via Rhodamine-123 efflux assay.

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  • Gene expression quantified using RT-PCR.

    • Main Results:

    • Mature lymphoid malignancies, particularly T-cell and NK-cell types, frequently expressed P-gp/MDR1.
    • In acute myeloid leukemia (AML), P-gp/MDR1 expression correlated with CD7, c-kit, and 8;21 chromosomal translocation, indicative of hematopoietic stem cell characteristics.
    • P-gp/MDR1 expression was more frequent at disease onset than relapse, likely due to the expansion of P-gp expressing cells.

    Conclusions:

    • P-gp/MDR1 expression is prevalent in T-cell, NK-cell, and stem cell-derived hematological malignancies.
    • Expression patterns reflect the characteristics of the normal counterpart cells.
    • Findings provide insights into drug resistance mechanisms in these cancers.