Related Experiment Video
Updated: Aug 19, 2026

Chronic Transcranial Electrical Stimulation and Intracortical Recording in Rats
Published on: May 11, 2018
Anticonvulsant effect of intraventricular antiepileptic drugs. Experimental study
J M González-Darder1, M García-Teno
1Department of Neurosurgery, Faculty of Medicine, University of Cádiz, Spain.
Abstract:
The effect of intraventricular administration of antiepileptic drugs on an experimental model of epileptic seizures in rats has been investigated. Animals were tested in the electroshock test measuring the time duration of the tonic phase of the convulsion. Drugs tested were sodium phenobarbital (200-500-1000 micrograms), phenytoin (50-100-200-500 micrograms), midazolam (100-200-500 micrograms) and sodium valproate (500-1000-2000 micrograms), delivered via a catheter stereotactically placed into the lateral ventricle. Control animals were tested with saline. All antiepileptic drugs showed different degrees of reduction in the duration of the tonic phase before reaching doses that produced neurological symptoms. Our results demonstrate the feasibility to control experimental seizures by means of intraventricular injection of antiepileptic drugs.
Related Concept Videos
Epilepsy and Seizures: Overview
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Antiepileptic Drugs: Sodium Channel Blockers
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
Antiepileptic Drugs: GABAergic Pathway Potentiators
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for their...
Antiepileptic Drugs: Glutamate Antagonists
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
Antiepileptic Drugs: Potassium Channel Activators
Ezogabine has gained approval as an adjunctive treatment...

