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Related Concept Videos

Pleura of the Lungs01:13

Pleura of the Lungs

The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
Pleural Disorders: Types and Brief Description01:30

Pleural Disorders: Types and Brief Description

The pleura is a vital part of the respiratory system. It's a double-layered membrane surrounding the lungs and lining the chest cavity. The two layers of the pleura are:
Pleural Effusion I: Introduction01:25

Pleural Effusion I: Introduction

Pleural effusion is an abnormal fluid accumulation in the pleural cavity, a narrow space between the lungs and the chest wall. It is not a disease per se but rather a symptom or indication of an underlying disease. In normal circumstances, this space contains a small amount of fluid (5 to 15 mL), a lubricant facilitating the non-frictional movement of the pleural surfaces.
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's criteria,...
Pleural Effusion II: Symptoms and Management01:28

Pleural Effusion II: Symptoms and Management

Pleural Effusion Overview
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
Pneumothorax-II01:27

Pneumothorax-II

Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
Pneumothorax II: Pathophysiology01:08

Pneumothorax II: Pathophysiology

Pneumothorax means the presence of air in the pleural space — the thin potential gap between the visceral and parietal pleura. This condition disrupts the normal pressure balance that keeps the lungs inflated, leading to partial or complete collapse of the affected lung.Normal physiologyUnder normal conditions, the pleural space maintains a slightly negative intrapleural pressure, which keeps the lungs expanded against the chest wall. This negative pressure creates a delicate balance between...

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Updated: May 10, 2026

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
07:54

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

Pleural effusion from malignancy

A Leff, P C Hopewell, J Costello

    Annals of Internal Medicine
    |April 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Treating malignant pleural effusion aims to obliterate the pleural space for palliative care. Bedside talc poudrage and pleurectomy are effective, but require careful patient selection due to potential toxicities and morbidities.

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    Last Updated: May 10, 2026

    Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
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    Published on: December 21, 2019

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    Local Anesthetic Thoracoscopy for Undiagnosed Pleural Effusion
    03:22

    Local Anesthetic Thoracoscopy for Undiagnosed Pleural Effusion

    Published on: November 10, 2023

    Area of Science:

    • Oncology
    • Pulmonology
    • Palliative Care

    Background:

    • Malignant pleural effusion significantly impairs respiratory function and can be fatal.
    • Palliative treatment focuses on obliterating the pleural space to improve quality of life and reduce hospitalizations.

    Purpose of the Study:

    • To review various medical and surgical methods for managing malignant pleural effusion.
    • To evaluate the efficacy and safety of different palliative treatment options.

    Main Methods:

    • Literature survey of medical agents (antineoplastics, antimicrobials, radioisotopes) and surgical techniques.
    • Specific mention of quinacrine, tetracycline, talc poudrage, and pleurectomy.

    Main Results:

    • Quinacrine and tetracycline show moderate to high efficacy, but quinacrine has substantial toxicity.
    • Bedside talc poudrage with thoracostomy-tube drainage is a safe and highly effective alternative.
    • Pleurectomy is definitive for preventing recurrence but associated with high morbidity and mortality.

    Conclusions:

    • Successful management of malignant pleural effusion requires pleural space obliteration.
    • Talc poudrage offers a safe and effective palliative option.
    • Pleurectomy provides definitive control but necessitates careful patient selection due to its risks.